PO-0996 Elevated Levels Of Interferon-inducible Protein 10 (ip-10) In Patients With 22q11.2 Deletion (digeorge) Syndrome
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چکیده
منابع مشابه
Elevated Levels of Interferon-inducible Protein-10 (IP)-10/CXCL10, but not of Interferon-γ, in Patients with Pulmonary Tuberculosis
Mycobacterial strains are potent inducers of cytokines/chemokines by mononuclear phagocytes, which constitute an important cellular component of the first line of defense in the innate immune system. Interferon (IFN)-γ-inducible protein (IP-10 or CXCL10) is a potent chemoattractant; however, little is known about the IP-10 profiles attributable to the Th1 regulation associated with active tuber...
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BACKGROUND Chemokines are a large group of chemotactic cytokines that regulate and direct migration of leukocytes, activate inflammatory responses, and are involved in many other functions including regulation of tumor development. Interferon-gamma inducible-protein-10 (IP-10) is a member of the C-X-C subfamily of the chemokine family of cytokines. IP-10 specifically chemoattracts activated T l...
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Coinfection with hepatitis C virus (HCV) and human immunodeficiency virus (HIV) is associated with an accelerated course of HCV infection and a faster progression to severe liver disease. We have investigated whether the development of liver disease in coinfected patients is associated with specific chemokine and cytokine production. Four cohorts--HCV/HIV-coinfected patients, HCV-monoinfected p...
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Ulcerative colitis (UC) is a chronic, relapsing inflammatory bowel disease (IBD) affecting the colonic mucosa; it is of unknown etiology (Baumgart & Carding, 2007). UC clinically displays bloody diarrhea, abdominal pain and weight loss, and often leads to a severe outcome since the therapeutic approaches, including corticosteroid and 5-aminosalicylic acid, are not always successful in inducing ...
متن کاملBIOCHEMICAL CHARACTERIZATION OF A y INTERFERON-INDUCIBLE CYTOKINE (IP-10)
The cellular immune response is characterized by the complex interaction of many different cells responding to multiple extracellular signals. Activation, proliferation, and directed migration of both local and blood-borne cells is partly regulated by soluble mediators released by cells, referred to collectively as cytokines. IFN-y, a glycoprotein secreted from activated T cells, has potent imm...
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ژورنال
عنوان ژورنال: Archives of Disease in Childhood
سال: 2014
ISSN: 0003-9888,1468-2044
DOI: 10.1136/archdischild-2014-307384.1614